Bills Only NFL Team To Be the Moneyline Favorites for Every 2025 Game

Posted on: May 26, 2025, 04:49h. 

Last updated on: May 26, 2025, 04:49h.

  • Bills only NFL team to be betting favourites in all 17 regular season games
  • Questions remain with roster, led by RB Cook’s contract status
  • Bills open the season at home primetime Sept. 7 against the Baltimore Ravens

Buffalo Bills’ quarterback Josh Allen, the reigning National Football League MVP, understandably has other priorities these days, most notably his wedding to actress Hailee Steinfeld. 

The Buffalo Bills, led by QB Josh Allen, the reigning NFL MVP, is the only team down as betting favourite in every one of their 17 regular season games for 2025. Image/Shutterstock.

Chiefs Still Bills’ Nemesis

Details on the nuptials have been kept under wraps. A teammate of Allen’s, Dion Dawkins may have tipped their hand, telling Good Morning Football it was “soon to come, May 31.” If that’s true, and he has that off his plate by this weekend, then Allen can focus on the football task at hand.

ESPN BET has the Bills favored in all 17 regular season games, the only team where that’s the case. That doesn’t happen very often and is an indicator of the expectations the Bills face.

Even the Kansas City Chiefs, the Bills’ nemesis, is the underdog for their Nov. 2 game in Buffalo (Moneyline Bills -150, Chiefs +130).

Betting Favourites Opening Night 

That’s the only Chiefs game where they aren’t favoured. The Bills also are favoured by ESPN BET for their home opener against the Ravens (Moneyline -125, Ravens +105). The Ravens are also favoured in all of their other games.

Allen just turned 29, has a new six-year USD $330 million contract in his pocket but doesn’t have a Super Bowl to his name, so that reality swings over his head like an anvil, and it’s only going to get tougher every year he doesn’t win one, as he soon heads into his 30s. 

The Bills will be the focus of Hard Knocks during training camp, which gets going July 24. That’s the first time that’s ever happened. OTAs get going tomorrow. The team is coming off its fifth straight AFC East title. According to this story, the Bills have collected the most bets at ESPN BET to win the Super Bowl this year since the 2025 schedule was released. The Bills will be featured in prime-time NFL games four of their first six games. 

Team Still Needs Work

Then there’s the near completion of the USD $2.1 billion Highmark Stadium, with some uncertainty over when it will be open. Will they be ready for the 2026 season, as had been reported? The stadium being opened and completed are two different things, this news report detailed. There will likely be construction going on after the building has been deemed by the county to be safe to occupy.

So these are heady days for the Bills and Allen. Still, the oddsmaker’s confidence in the Bills is at odds with some of the critique the team has been seeing this offseason. 

They have a festering contract issue with running back James Cook, who had a great 2024 (back-to-back 1,000-yard rushing seasons to his name), and is in the last year of his rookie contract. The Bills are a different team with Cook on the field. 

Eagles Betting Favourites to Win Super Bowl

CBS reported Cook is looking for a deal that will pay him USD $15 million per season (like what RB Derrick Henry just got from the Baltimore Ravens, two years at USD $30 million). The team has control there, but do they want a disgruntled Cook reporting to camp in July?

Questions remain at cornerback too. Rasul Douglas appears to be gone, with the team bringing Tre’Davious White back while drafting Maxwell Hairston with their first pick in April’s NFL draft. The Bills focused on defence this off-season – bringing in edge rusher Joey Bosa, drafting DT T.J. Sanders (round 2), DE Landon Jackson (round 3), DT Deone Walker (round 4), and DB Jordan Hancock (round 5) before taking TE Jackson Hawes later in the fifth round.

Do the Bills finally have the team to get over the hump and beat the Kansas City Chiefs if they face them again in the playoffs this season? That’s the bigger question – all that despite the oddsmaker’s confidence in the team this upcoming regular season.

BetMGM still favours the Philadelphia Eagles (+650) and Ravens (+700) over the Bills (+750) to win the Super Bowl.